個人簡介

學歷/經歷

學歷

  • 國立成功大學 醫學工程博士
  • 國立成功大學 醫學工程碩士
  • 國立中山大學 機械工程學士

    • 經歷

  • 亞洲大學研究發展處副研發長(2021/8~迄今)
  • 亞洲大學生物資訊與醫學工程系副教授 (2015/3~迄今)
  • 亞洲大學生物與醫學資訊學系助理教授 (2008/2~2015/2)
  • 美國西雅圖華盛頓大學(University of Washington, Seattle)訪問學者 (2005/8~2006/3)
  • 嘉南藥理大學嬰幼兒保育系兼任講師
  • 中華民國生物醫學工程學會會員
  • 臺灣化學感測器科技協會會員

    • 研究興趣

    我的研究興趣重點在生物感測技術的開發和應用，特別是在表面電漿共振生物感測器方面。 近年來，研究的主題也涉及核酸適體與標的蛋白的電腦模擬計算與篩選的工作，應用篩選出的核酸適體於感測技術上以檢測特定的蛋白質分子。

    • 生醫感測技術
    • 核酸適體
    • 分子模擬
    • 生物力學

    發表成果

    期刊論文

    •  Wen-Pin Hu, Yu-Ming Wu, Cao-An Vu, Wen-Yih Chen*, "Ultrasensitive detection of interleukin 6 by using silicon nanowire field-effect transistors." Sensors, 23(2), 625, (2023). (SCI )
    •  Wei-Ching Hsu, Li-Wei Chou, Hsiao-Yen Chiu, Chang-Wei Hsieh*, Wen-Pin Hu*, "A study on the effects of lateral wedge insoles on plantar pressure pattern for medial knee osteoarthritis using the wearable sensing insole", Sensor, 23(1), 84, (2023). (SCI )
    • Yu-Chao Lin, Wen-Yih Chen, En-Te Hwu, Wen-Pin Hu*, "In-silico selection of aptamer targeting SARS-CoV-2 spike protein" International Journal of Molecular Sciences, 23(10), 5810 (2022). (SCI)
    • Hui-Ting Lin, Hsin-Jen Tsai, Yen-I Li, Wen-Pin Hu, "Benefits of applying virtual reality in pelvic movement training through a Wii Fit: a randomized controlled trial", BMC Medical Education, 22, 47 (2022). (SCI)
    • Wen-Teng Liu, Wen-Pin Hu, Chung-Liang Lai, Yu-Yawn Chen, Kuen-Chang Hsieh, "Validation of three bioelectrical impedance analysis for the assessment of appendicular lean tissue in older community-dwelling adults" International Journal of Gerontology, 15(4), 377-381, 2021. (SCI)
    • Li-Wei Chou, Jun-Hong Shen, Hui-Ting Lin, Yi-Tung Yang, Wen-Pin Hu*, "A Study on the Influence of Number/Distribution of Sensing Points of the Smart Insoles on the Center of Pressure Estimation for the Internet of Things Applications" Sustainability 13, no. 5: 2934, 2021. doi: https://doi.org/10.3390/su13052934 (SCI)
    • Wen-Yih Chen, Daumantas Matulis, Wen-Pin Hu, Yi-Fang Lai, Wei-How Wang, “Studies of the Interactions Mechanism between DNA and Silica Surfaces by Isothermal Titration Calorimetry”, Journal of the Taiwan Institute of Chemical Engineers, 116, 62-66, 2020. doi: https://doi.org/10.1016/j.jtice.2020.11.019. (SCI)
    • Wen-Pin Hu, Yu-Chi Chen, Wen-Yih Chen*, "Improve sample preparation process for miRNA isolation from the culture cells by using silica fiber membrane", Scientific Reports, 10, Article number: 21132, 2020. doi: https://doi.org/10.1038/s41598-020-78202-8. (SCI)
    • 簡廷翰、胡文品、蘇文郁、林其鋒、陳冠霖、魏暘(2020)。仿貽貝黏膠設計－具黏附性質之胜肽序列探討。化工。第67卷第3期，頁65-72。
    • Cao-An Vu, Wen-Pin Hu, Yuh-Shyong Yang, Hardy Wai-Hong Chan, Wen-Yih Chen, “Signal enhancement of silicon nanowire field-effect transistor immunosensors by RNA aptamer”, ACS Omega, Sep, 2019, DOI: 10.1021/acsomega.9b01264 (SCI)
    • Wei-Cheng Chou, Wen-Pin Hu, Yuh-Shyong Yang, Hardy Wai-Hong, Wen-Yih Chen, “Neutralized chimeric DNA probe for the improvement of GC-rich RNA detection specificity on the nanowire field-effect transistor”, Scientific Reports, 9, Article number: 11056 (2019). doi: https://doi.org/10.1038/s41598-019 -47522-9. (SCI)
    • Hui-Ting Lin, Yen-I Li, Wen-Pin Hu, Chun-Zheng Huang, Yi-Chun Du, “The efficacy of virtual reality on patients of musculoskeletal system pathology: A systematic review”, Journal of Clinical Medicine, 8(6): 791, 2019. 2019 Jun; . doi: 10.3390/jcm8060791. (SCI)
    • Wen-Pin Hu, Chih-Chin Tsai, Yuh-Shyong Yang, Hardy Wai-Hong Chand, Wen-Yih Chen, "Synergetic improvements of sensitivity and specificity of nanowire field effect transistor gene chip by designing neutralized DNA as probe", Scientific Reports, 8, Article number: 12598, 2018. doi: https://doi.org/10.1038/s41598- 018-30996-4. (SCI)
    • Wen-Pin Hu, Chin-Bin Lin, Cheng-Ying Yang, Min-Shiang Hwang, "A framework of the intelligent plant factory system", Procedia Computer Science, 131, 579-584, 2018. https://doi.org/10.1016/j.procs.2018.04.295 (Scopus & EI)(/li)
    • Pi-Chou Hsieh, Hui-Ting Lin, Wen-Yih Chen, Jeffrey J. P. Tsai, Wen-Pin Hu*, "The Combination of Computational and Biosensing Technologies for Selecting Aptamer against Prostate Specific Antigen," BioMed Research International, vol. 2017, Article ID 5041683, 2017. doi:10.1155/2017/5041683. (SCI)
    • Wen-Pin Hu*, Jangam Vikram Kumar*, Chun-Jen Huang, Wen-Yih Chen "Computational selection of RNA aptamer against angiopoietin-2 and experimental evaluation", BioMed Research International, 2015, Article ID 658712, doi: http://dx.doi.org/10.1155/2015/658712, 2015. (SCI)
    • Jangam Vikram Kumar, Jeffrey J. P. Tsai, Wen-Pin Hu* and Wen-Yih Chen, "Comparative Molecular Simulation Method for Ang2/Aptamers with in vitro Studies", International Journal of Pharma Medicine and Biological Sciences, 4(1), 61-64, January 2015.
    • W. P. Hu*, J. V. Kumar, Jeffrey J. P. Tsai, "Computational analysis of potential inhibitors selected based on structural similarity for the Src SH2 domain", International Journal of Medical, Health, Pharmaceutical and Biomedical Engineering, 8(7), 327-330, 2014.
    • Jangam Vikram Kumar, Wen-Yih Chen, Jeffrey J.P. Tsai, Wen-Pin Hu*, "Molecular simulation methods for selecting thrombin-binding aptamers," Lecture Notes in Electrical Engineering, 253, 743-749, 2013. (EI)
    • Wen-Yih Chen*, Hon-Chen Chen, Yuh-Shyong Yang, Chun-Jen Huang, Hardy Wai-Hong Chan and Wen-Pin Hu*, "Improved DNA detection by utilizing electrically neutral DNA probe in field-effect transistor measurements as evidenced by surface plasmon resonance imaging", Biosensors & Bioelectronics, 41, 795??01, 2013. (SCI)
    • Wen-Pin Hu, Li-Ya Huang, Wen-Yih Chen, "Optimal buffer pH value on the detection of HSA by using a protein chip prepared by DNA-directed immobilization", Applied Mechanics and Materials, 284-287, 398-402, January 2013. (EI)
    • Wen-Pin Hu, Li-Ya Huang, Tai-Chih Kuo, Wei-Wen Hu, Yung Chang, Chien-Sheng Chen, Hong-Cheng Chen, Wen-Yih Chen*, "Optimization of DNA directed immobilization on mixed oligo (ethylene glycol) (OEG) monolayers for immunodetection," Analytical Biochemistry, 423, 26-35, 2012. (SCI)
    • Tung-Hao Chang , Zhen-Wen Chen , Wen-Pin Hu*, Intact lung extraction in the 2D computer topography image by using a K-cosine corner detection method," Asian Journal of Arts and Sciences, 2(1), 1-15, 2011.
    • W.-Y. Chen, W.P. Hu, Y.-D. Su, A. Taylor, S. Jiang, G.L. Chang, "Amultispot DNA chip fabricated with mixed ssDNA/Oligo (ethylene glycol) self-assembled monolayers for detecting the effect of secondary structures on hybridization by SPR imaging," Sensors & Actuators B: Chemical, 125, 607-614, 2007. (SCI)
    • Wen-Pin Hu, Guan-Liang Chang, Shean-Jen Chen and Yu-Min Kuo, "Kinetic analysis of beta-amyloid peptide aggregation induced by metal ions based on surface plasmon resonance biosensing," Journal of neuroscience methods, 154, 190-197, 2006. (SCI)
    • W.P. Hu, H.-Y. Hsu, A. Chiou, K.Y. Tseng, H.-Y. Lin, G.L. Chang, S.-J. Chen, "Immunodetection of pentamer and modified C-reactive protein using surface plasmon resonance biosensing," Biosensors & Bioelectronics, 21, 1631-1637, 2006. (SCI)
    • W. P. Hu, S.-J. Chen, K.-T. Huang, J. H. Hsu, W. Y. Chen, G. L. Chang, and K.-A. Lai, "A novel ultrahigh-resolution surface plasmon resonance biosensor with an Au nanocluster-embedded dielectric film," Biosensors & Bioelectronics, 19, 1465-1471, 2004. (SCI)
    • C. Y. Yu, K. H. Tsai, W. P. Hu, R. M. Lin, H. W. Song, G. L.Chang, "Geometric and morphological changes of the intervertebral disc under fatigue testing," Clinical Biomechanics. 18(6) Jul :S3-9, 2003. (SCI)
    • K.-A. Lai, W.-J. Shen, C.-H. Chen, C. Y. Yang, W. P. Hu, G. L. Chang, "Failure of HA-coated acetabular cups-10-year follow up of 85 Landos Atoll arthroplasties," The Journal of Bone and Joint Surgery, 84(B): 641-646, 2002. (SCI)
    • K.-A. Lai, C. C. Lee, J.-H. Lin, W. P. Hu, G. L. Chang, C. Y. Yang, "Retrieval study of failed HA coated acetabular cups," Journal of Orthopedics Surgery ROC, 18: 7-13, 2001.
    • W.P. Hu, K.-A. Lai, I.-M. Jou, J.-H. Lin, G. L. Chang, "Study of the hydroxyapatite- coated acetabular cups retrieved at revision surgery-Relation of the residual HA to the failure modes," Journal of musculoskeletal research, 5(4), 217-224, 2001.

    書籍/章節

    • Wen-Pin Hu*, Hui-Ting Lin, Wen-Yih Chen and Jeffrey J. P. Tsai1 (2020) A study on the effect of an aptamer with an embedded phosphate-methylated nucleotide on the binding of a target molecule using molecular simulation. In: J. C. Hung et al. (Eds.): Frontier Computing. FC 2019, Lecture Notes in Electrical Engineering, vol 551, pp. 31–38. Springer, Singapore (Print ISBN: 978-981-15-3249-8) (EI indexed)
    • Wen-Pin Hu, Hui-Ting Lin, Wen-Yu Su, Rouh-Mei Hu, Wei Yang, Wen-Yih Chen, Jeffrey J. P. Tsai (2019) The selection of DNA aptamers against the Fc region of human IgG. In: Hung J. C., Yen N. Y., Hui L. (Eds.) Frontier Computing (FC) 2018. Lecture Notes in Electrical Engineering, vol 542, pp 11-19. Springer, Singapore (Print ISBN: 978-981-13-3647-8) (EI indexed)
    • Wen-Pin Hu, Hui-Ting Lin, Jeffrey J. P. Tsai, Wen-Yih Chen (2017). Investigating interactions between proteins and nucleic acids by computational approaches. In Jeffrey J. P. Tsai,‎ Ka-log Ng (1st Edition), Computational Methods with Applications in Bioinformatics Analysis (Advanced Series in Electrical and Computer Engineering)(pp.98-117), World Scientific Pub Co Inc. (ISBN-13: 978-9813207974；ISBN-10: 9813207973)
    • Hui-Ting Lin, Yang Wei, Wen-Yu Su, Chun-Ju Chan, Wen-Yih Chen, Jeffrey J. P. Tsai and Wen-Pin Hu (2018) A Study on the Binding Ability of Truncated Aptamers for the Prostate Specific Antigen Using Both Computational and Experimental Approaches. In: Hung J., Yen N., Hui L. (eds) Frontier Computing. FC 2017. Lecture Notes in Electrical Engineering, vol 464, pp 46-55. Springer, Singapore (Print ISBN: 978-981-10-7397-7) (EI indexed)

    研討會論文

    • Wen-Teng Liu, Li-Wei Chou, Yi-Tung Yang, Yi-Tung Yang, Wen-Pin Hu* “Accuracy of COP trajectory estimation with different numbers of pressure sensors on the insole”, International Conference on Innovative Computing and Management Science (ICMS) 2020, July 29- July 31, 2020, Yilan, Taiwan (Oral).
    • Wen-Pin Hu, Hui-Ting Lin, Wen-Yih Chen, Jeffrey J. P. Tsai, “A study on the effect of an aptamer with an embedded phosphate-methylated nucleotide on the binding of a target molecule using molecular simulation”, The 8th International Conference on Frontier Computing (FC 2019), Kitakyushu, Japan, July 9-12, 2019. (Oral)
    • Shen, W.-C., Lu, J.-H., Chien, H.-W., Wu, W.-T., Hu, W.-P., Lung, C.-W., 2018. Using Skin Microcirculation Service for Monitoring Ulcer Recovery in Medical Service, International Conference of Service Science and Innovation (ICSC 2018) and Serviceology (ICSet 2018). Society for Serviceology, Taichung, Taiwan, Nov 13-15-6, 2018. (Oral)
    • Wen-Pin Hu, Hui-Ting Lin, Wen-Yu Su, Rouh-Mei Hu, Yang Wei, Wen-Yih Chen and Jeffrey J. P. Tsai, "The selection of DNA aptamers against the Fc region of human IgG", The 7th International Conference on Frontier Computing (FC 2018), Kuala Lumpur, Malaysia, July 3-6, 2018. (Oral)
    • Wen-Pin Hu, Chin-Bin Lin, Cheng-Ying Yang, Min-Shiang Hwang, "A framework of the intelligent plant factory system", The 8th International Congress of Information and Communication Technology (ICICT2018), Procedia Computer Science （ISSN: 1877-0509） by ELSEVIER , Xiamen, China, on January 27-28, 2018. (EI/Scopus).
    • Hui-Ting Lin, Yang Wei, Wen-Yu Su, Chun-Ju Chan, Wen-Yih Chen, Jeffrey J. P. Tsai and Wen-Pin Hu, A study on the binding ability of truncated aptamers for the prostate specific antigen using both computational and experimental approaches. The 6th International Conference on Frontier Computing (FC 2017), Osaka, Japan, July 12-14, 2017. (Oral)
    • Wen-Pin Hu*, Chun-Jen Huang and Wen-Yih Chen, The selection of PSA-specific DNA aptamers by using computational approaches and biosensors. Asian Conference on Chemical Sensor (ACCS2015), Malaysia, November 16-18, 2015. (Oral)
    • Wen-Pin Hu*, Jangam Vikram Kumar, Wen-Yih Chen, Jeffrey J.P. Tsai, Docking and molecular dynamics simulation studies of CDK2 inhibitors and potential compounds. 7th WACBE World Congress on Bioengineering 2015, Malaysia, July 6-8, 2015. (Poster)
    • W. P. Hu, J. V. Kumar, Jeffrey J. P. Tsai, Computational analysis of potential inhibitors selected based on structural similarity for the Src SH2 domain. International Conference on Mechanical and Biomedical Engineering 2014 (ICMBE 2014), published in International Journal of Medical, Health, Pharmaceutical and Biomedical Engineering, 8(7), 327-330, 2014.
    • Jangam Vikram Kumara, Wen-Yih Chen, Jeffrey J. P. Tsai, and Wen-Pin Hu*, Comparative molecular simulation method for ang2/aptamers with in vitro studies. International Conference on Biomedical Engineering and Technology-ICBET 2014, Mar 12-14, 2014. (Oral)
    • Wen-Pin Hu*, Wen-Yih Chen, Cheng-Cheng Ho, Hong-Cheng Chen , Ka-Lok Ng, The spacer effect of probe DNA on the hybridization studied by a surface plasmon resonance imaging. World congress on medical physics and biomedical engineering, China, May 26-31, 2012. (Oral)
    • Wen-Pin Hu, The measurements of biomolecular interactions by surface plasmon resonance techniques, Biocomputation Forum 2010 at Asia University, Taichung, November 2010. (Oral)
    • Ta-Cheng Chen, Jing-Doo Wang, Jiunn-I Shieh, Kuei-Jen Lee, Wenpin Hu, Pei-Chun Chang and Hsiang-Chuan Liu. Detection of epilepsy events in the EEG by mimetic signatures and nonlinear dynamic indications., International Conference on Bioinformatics (InCoB), 2009. (Poster)
    • W.P. Hu, S.-J.Chen, J.-N. Yih, G.-Y. Lin, G.L. Chang. Studying protein structural change based on surface plasmon resonance and surface-enhanced Raman scattering., Proc. SPIE, 5327, 88-94, 2004. (Oral)
    • W.P. Hu, K.A. Lai, C.H. Lin, C.Y. Yang, G.L. Chang. Retrieval study on hydroxyapatite- coated acetabular cups., Proceedings of the IEEE 28th annual northeast bioengineering conference, 5-6, 2002. (Poster)
    • Wen-Pin Hu, Kuen-Horng Tsai, Ruey-Mo Lin, Chin-Yin Yu, Horng-Woei Song, and Guan-Liang Chang. Spinal injures of end-plate and disc under cyclic compressive testing? comparison between MRI and anatomic findings., International conference on biomechanics combined with the annual scientific meeting of Taiwanese Society of Biomechanics, 40, 2001. (Oral)

    聯絡方式

    辦公室: HB22
    電話: +886-4233456 ext.20022
    電子郵件: wenpinhu@asia.edu.tw
    地址: 台中市霧峰區柳豐路500號 生物資訊與醫學工程系